The game features several aesthetical details found in real televised NBA games, such as commentary from Kevin Harlan, Clark Kellogg, and Steve Kerr, sideline reports from Doris Burke, halftime shows, replays, customizable camera angles, and other details.

Players mostly play NBA basketball games with real or created players and teams. NBA 2K12 is a basketball simulation game which strives to emulate the National Basketball Association. By April 2012, the game had sold over four million copies worldwide. NBA 2K12 received positive reviews from critics upon release, with praise directed at the visuals, wealth of content, controls, and overall gameplay. A contest was held before the game's release, the winners of which would collaborate on an original song to be featured in the game. The game features a licensed soundtrack consisting of 28 songs. In September 2011, prior to the game's release, a demo was released for PlayStation Network and Xbox Live. A mode focusing on past NBA players is introduced, and several online modes are present.

A mode called Association is also present, in which the player assumes control of an NBA organization, and simulates through seasons. MyPlayer mode is one of the modes in it, players create their own player and play through their career in the NBA. Players mainly play NBA basketball games in a variety of game modes with real and customizable players and teams. NBA 2K12, like the other games in the series, strives to emulate the experience of the National Basketball Association. This was the last installment in the series to be released for the PlayStation 2. For the first time in the series, three different covers are available the three cover athletes are Michael Jordan (who was also the cover athlete for the previous game) for the Chicago Bulls, Magic Johnson of the Los Angeles Lakers, and Larry Bird of the Boston Celtics. As the thirteenth installment in the NBA 2K series, it is the successor to NBA 2K11 and the predecessor to NBA 2K13. It was released in October 2011 for Microsoft Windows, PlayStation 2, PlayStation 3, PlayStation Portable, Wii, Xbox 360, and, for the first time, iOS.

NBA 2K12 is a 2011 basketball simulation video game developed by Visual Concepts and published by 2K Sports.

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